Making his debut during the 1996/97 season, Jaffer has played first-class cricket for Mumbai and Vidarbha.

In the 150th Ranji Trophy match, he became the player with most appearances in India's premier domestic competition.

He also the first cricketer in the history of Ranji Trophy to go past 11,000 runs in 2018.

He played 31 Tests for India and scored 1,944 runs with 5 centuries and 11 half-centuries at an average of 34.10  and also has two double centuries to his credit on the international arena (212 vs West Indies and 202 vs Pakistan).