Many people who refuse to get vaccinated against COVID-19 say they don’t trust the technology behind mRNA vaccines, such as in BioNTech-Pfizer and Moderna shots. They say they also don’t trust vector-based vaccines, like the Oxford-AstraZeneca and Johnson & Johnson jabs. Many say they are instead waiting for protein-based vaccines, which have proven themselves over years as providing safe protection, for example against influenza, tetanus and whooping cough. Now, the European Medicines Agency (EMA) has approved the first protein-based vaccine, produced by American company Novavax, against SARS-CoV-2. Protein-based vaccines appear to offer a good level of protection against COVID-19 and produce fewer side effects than those existing and approved mRNA and vector-based vaccines.