Physical inactivity along with risk factors like depression, diabetes, dyslipidemia, hypertension, obesity, excess weight, and smoking may lead to heart disease, which is one of the leading causes of death in the world, representing 31 per cent of global mortality, the study says. To measure the impact of physical fitness on heart disease risk factors, the researchers selected 205 men and 44 women with heart disease, including coronary artery disease, stroke, congestive heart failure, and heart valve disease, and had them undergo a cycle ergometer (stationary bike) stress test to determine their fitness level. The results showed that normal physical fitness, even up to 20 per cent below the population average, is sufficient to have a preventive effect on five of the eight risk factors affecting people with cardiovascular disease--abdominal circumference, diabetes, hypertension, obesity, and excess weight.