Early-life exercise promotes healthy brain

New York

The research indicates that there may be a window of opportunity during early human development to optimise the chances of better lifelong health.

"Exercise affects many aspects of health, both metabolic and mental, and people are only now starting to look at the plasticity of these gut microbes," said senior study author Monika Fleshner from University of Colorado Boulder in the US.

Microbes take up residence within human intestines shortly after birth and are vital to the development of the immune system and various neural functions. The human gut harbours over 100 trillion microorganisms.

These microbes can add as many as five million genes to a person's overall genetic profile and thus have tremendous power to influence aspects of human physiology.

While this diverse microbial community remains somewhat malleable throughout adult life and can be influenced by environmental factors such as diet and sleep patterns, the researchers found that gut microorganisms are especially 'plastic' at a young age.

The study found that juvenile rats who voluntarily exercised every day developed more beneficial microbial structure, including the expansion of probiotic bacterial species in their gut compared to adult rats, even when the adult rats exercised as well.

A robust, healthy community of gut microbes also appears to promote healthy brain function and provide anti-depressant effects, Fleshner explained.

The researchers have not pinpointed an exact age range when the gut microbe community is likeliest to change, but the preliminary findings indicated that earlier is better.

The study was published in the journal Immunology and Cell Biology.