In a mishap, 22 people, including nine children, froze to death in vehicles stranded due to heavy snow in the country's north Murree region as thousands of tourists flocked to the resort area, which created a big management crisis, Nouman-ul-Haq, an official from the National Disaster Management Authority, told Xinhua news agency.
He added that entry of tourists to the hill station would be banned for the next two days.
Around 1,000 cars have been stuck in Murree as authorities launched a full-fledged operation to rescue the stranded people, with locals providing them food and blankets to help them combat the chilly weather.
At least 20 others were killed in other parts of Pakistan owing to extreme weather conditions, the official said.
According to rescue officials in the Khyber Pakhtunkhwa province, nine people were killed and 10 others injured in various rain and snowfall-related incidents on Friday and Saturday.
Similarly, heavy rains also claimed the lives of 11 people in Punjab and Balochistan provinces, whereas dozens of people also sustained injuries.
Personnel of the Pakistan Army, Navy and paramilitary Frontier Corps are assisting local governments in rescue and relief operations in the affected areas of the country. Hundreds of people have been shifted to safe places after torrential rains damaged their houses in Balochistan, the worst affected region in the wet spell.
According to a statement of the Pakistan Meteorological Department, heavy rains with snowfall over the hills are expected in parts of the country until Sunday.
Heavy rainfall may generate flash flooding in vulnerable parts of the country, said the weather department, adding that heavy snowfall in hilly areas may cause road closures and all the concerned authorities should remain alert during the forecast period.
The heavy rains and snowfall also disrupted travel across Pakistan.
More than 20 flights to and from Lahore were cancelled or diverted owing to the inclement weather, sources from the city's Allama Iqbal International Airport told Xinhua.
The bad weather affected the train services in the country, where passengers had to face long delays, with authorities urging people to only make necessary travels during the forecasted period and get details of their flights or train departures.
Many residents have reported power outages in several parts of Pakistan due to the inclement weather.