The al-Ahram daily reported the crash took place when a passenger microbus collided with a truck on a highway that links Cairo's outskirts on the banks of the Nile River.
Another state-run daily, Akhbar el-Yom said the truck crossed to the wrong side of the highway and collided head-on with the microbus.
Footage circulating online purported to show bodies lying on the roadside as ambulances rushed to pick up casualties.
Traffic accidents kill thousands every year in Egypt, which has a poor transportation safety record. Crashes are mostly caused by speeding, bad roads or poor enforcement of traffic laws.
Last month, a bus overturned on a highway linking Cairo with the city of Suez, killing at least 12 people and injuring 30 others. In April, a bus overturned while trying to pass a truck on a highway in the southern province of Assiut, leaving at least 21 people dead and three others injured.
Egypt's official statistics agency says around 10,000 road accidents took place in 2019, the most recent year for which statistics are available, leaving over 3,480 dead. In 2018, there were 8,480 car accidents, causing over 3,080 deaths.