The victims belonged to Lion Tanda, a tribal hamlet near Nuzividu, about 55 kms from Vijayawada, and were on their way to a nearby village in an autorickshaw when an unidentified vehicle rammed into it, police said.
While six workers died on the spot, eight were injured.
The injured were rushed to hospitals in Nuzividu and Vijayawada.
Nuzividu sub-divisional police officer Srinivasulu said they have registered a case and launched a hunt to trace the vehicle that caused the accident.
Andhra Pradesh Governor Biswabhusan Harichandan, Deputy Chief Minister (Health) A K K Srinivas, Home Minister M Sucharita, TDP president N Chandrababu Naidu and Jana Sena chief K Pawan Kalyan expressed grief over the mishap.
Srinivas directed the Krishna district medical officer to ensure better treatment to the injured persons. He promised government assistance to the kin of the deceased.