As many as 52 people succumbed to the virus, pushing the death toll to 10,423. Active cases, including those in isolation, was at 42,566.
According to the department bulletin, 95,538 samples were examined on Wednesday, pushing the tally to 85,84,041 till date.
A private lab in neighbouring Kancheepuram district received approval for conducting COVID-19 tests, taking the total number of facilities operating in the State to 192.
Among the districts, Chennai logged 1,130 new cases followed by Coimbatore 389, Salem 274, Chengalpattu 272 and Tiruvallur 207.
Cuddalore, Erode, Kancheepuram, Namakkal, Tiruppur and Vellore saw their infection count go up by 100 new cases each.
Of the 52 deceased, 33 people were above 60 years. Meanwhile, AMMK treasurer Vetrivel, who contracted the virus and had been admitted at the Sri Ramachandra Hospital here continues to be critical, a hospital release stated.