Both sides go into the match after important wins in the Champions League, although Manchester United rode their luck slightly to come back from 2-0 down against Atalanta and there is still a feeling that coach Ole Gunnar Solskjaer hasn't worked out how to get the best of the wealth of attacking talent in his squad.
Perhaps Liverpool have fewer options to rotate in attack than United, but with Mohamed Salah inarguably the best form of his career, Jurgen Klopp's side will feel confident of inflicting damage to a defense that conceded twice in midweek and four times last weekend away to Leicester City.
The weekend kicks off with Arsenal taking on Aston Villa in a mid-table game before Chelsea defend their leadership at home to winless Norwich City on Saturday lunchtime.
Romelu Lukaku and Timo Werner will both miss out for Chelsea due to injury, meaning that Kai Havertz and Callum Hudson-Odoi should get the chance against a rival that has tightened up in defense in their last two games to take draws against Burnley and Brighton, reports Xinhua.
Despite consecutive draws, Brighton currently sit fourth in the table, but Manchester City will provide a litmus test to their hopes of gatecrashing into Europe this season.
Both sides look to play attractive passing football, although Brighton have also formed a rock-solid defense, that has conceded just five goals and helps to cover for their problems scoring goals, with just eight all season -- half the total of Saturday's rivals.
Graeme Jones is temporarily in the Newcastle United dugout following the sacking of Steve Bruce during the week. Newcastle still have to climb out of the relegation zone. It will be interesting to see how their players react to Bruce's departure, with Jones considered tactically more adaptable than his predecessor.
Claudio Ranieri takes his Watford team to face Everton looking to recover from the 5-0 thrashing against Liverpool on his debut. Everton are handicapped by injuries to key players such as Abdoulaye Doucoure, Andre Gomes, Fabian Delph, Richarlison and Dominic Calvert-Lewin.
Leeds are also affected by injuries for their home game against Wolves with Patrick Bamford, Kalvin Phillips, Robin Koch, Junior Firpo and Luke Ayling all sidelined against the rivals who have won their last three games and are gaining in confidence.
Southampton and Burnley need to find a bigger punch in front of goal in their game, which looks likely to be a close affair before Sunday sees what promises to be a high-intensity game between Brentford, who were very unlucky to lose to Chelsea a week ago, and Leicester, who have scored four goals in each of their last two games, with Patson Daka netting all four in their Europa League win in Moscow.
Finally West Ham host Tottenham after both sides had differing fortunes in Europe on Thursday, with West Ham taking a big stride towards the knockout stage of the Europa League with a 3-0 win over Genk, while a completely changed Spurs side wilted in a 1-0 defeat to Vitesse Arnhem.