Punjab seamer Siddarth Kaul was included in the squad for the final T20I to be held at the MA Chidambaram Stadium here on Sunday.
"The Indian team management has decided to rest Umesh Yadav, Jasprit Bumrah and Kuldeep Yadav from the upcoming third Paytm T20I against the Windies in Chennai," BCCI acting secretary Amitabh Choudhary said in a release.
"The decision has been made to allow the trio to be in the best physical condition ahead of India's tour to Australia.
"The All-India Senior Selection Committee has added Siddarth Kaul to India's squad for the final T20I."
In the two games, left-arm spinner Kuldeep picked up five wickets, including 3 for 13 at Kolkata while Bumrah took three wickets.
Pacer Umesh was left out of the playing XI in the second match after the series.
Kaul, who made his T20I debut against Ireland in Dublin in June, has so far figured in two matches.
India have already sealed the T20 series by winning the first two matches in Kolkata and Lucknow respectively.
The Indian team members are likely to arrive in the city on Saturday.
Meanwhile, the West Indies players will have a training session under lights later in the evening.
India begins its tour of Australia with the opening T20I at Brisbane on November 21.
India's squad for the 3rd T20I: Rohit Sharma (c), Shikhar Dhawan, KL Rahul, Dinesh Karthik (wk), Manish Pandey, Shreyas Iyer, Rishabh Pant (wk), Krunal Pandya, Washington Sundar, Yuzvendra Chahal, Bhuvneshwar Kumar, Khaleel Ahmed, Shahbaz Nadeem, Siddarth Kaul.