Most people have mild reactions that disappear after a few days, such as low-grade fevers or muscle aches. Health experts say these are a sign of our bodies mounting an immune response and that signals we will likely be protected by the vaccine against future infections.
In the United States, health authorities say fewer than 0.001% of vaccinated people have had an extreme reaction, like an allergic response to a COVID vaccine. But people do get side effects. And increasingly, data suggests that women are much more likely to experience side effects than men — and that reflects a trend throughout the history of vaccination. In June, the Swiss government released data showing 68.7% of reported side effects to COVID vaccines came from women. In the US, that percentage was 79.1% for the first 13.7 million doses given to people — 61.2% of which had been administered to women. And in Norway it was 83% of the 722,000 people vaccinated as of early April. That’s just a handful of samples. Data on women’s side effects is scarce.
But Maria Teresa Ferretti, a neuroimmunologist at the Medical University of Vienna, says the data we have is unsurprising. Ferretti, who also founded a non-profit called Women’s Brain Project, says we already knew that men and women react differently to vaccination. “From vaccines for other viruses, we knew that women tend to produce more antibodies when they are vaccinated, which means they also tend to have more side effects,” she told DW.
One study, spanning 26 years from 1990 and 2016, found that women accounted for 80% of adult anaphylactic reactions to vaccines. Women were also found to be four times as likely to report an allergic reaction to an H1N1 vaccine used during the 2009 swine flu pandemic. Other research has suggested that sex hormones can influence the human immune system. A more robust immune response is also why more women tend to develop autoimmune diseases than men — the body goes into overdrive, attacking things that are meant to be there.
This difference is part of a bigger picture of how biological sex and gender both influence our health, says Rosemary Morgan, a gender and health researcher at the Johns Hopkins Bloomberg School of Public Health in the US. While women are more likely to suffer worse side effects from vaccines, men are more likely to be hospitalised for serious cases of COVID, and more men die of COVID. Biological factors affect our immune systems — whether we are born biologically male, female or intersex. Male immune systems, for example, have their own specific issues that apply less to female bodies. For instance, testosterone can be immuno-suppressive. But gender — considered a social construct; an idea in our heads — can also affects people’s behavior and access to healthcare. Men, for example, are often socialised to repress pain and, as a result, may be less likely to report adverse reactions.
“Studies show that men are less likely to wear masks and wash their hands. If you couple that with their biological risk, it’s this complex intersection that plays into men’s greater vulnerability to COVID-19,” Morgan told DW. Data on intersex, non-binary and transgender susceptibility to COVID is limited, but some research suggests that discrimination against gender and sexual minorities could mean they are disproportionately affected by COVID. And that’s possible around the world. The research suggests certain groups of people are being excluded from vital healthcare.
The Sex, Gender & COVID-19 project, a global tracker of sex-specific research by a non-profit called Global Health 50/50, shows only 37% of countries reported death data that specified the sex of the individual and 18% vaccination data that differentiated between sex in the month of June 2021. “There has been a historical lack of sex and gender analysis within medical and clinical research,” says Morgan. She says that it wasn’t until 1993 in the United States that women were mandated to be included in clinical trials.