Scientists, including those of Indian-origin, have resolved the structure of a molecule which the novel coronavirus uses to make its genetic sequence seem like a part of the host’s own, an advance that may lead to the development of new antiviral drugs against COVID-19.
According to the researchers, deciphering the 3D structure of nsp16 paves the way for the design of new drugs against the novel coronavirus SARS-CoV-2, and other emerging coronavirus infections. These drugs, Gupta said can be designed to inhibit nsp16 from making the modifications, so that the host immune system would pounce on the invading virus, recognising it as foreign. “Yogesh’s work discovered the 3D structure of a key enzyme of the COVID-19 virus. This is a fundamental advance in our understanding of the virus,” said study co-author Robert Hromas.