"We will hire 1,000 American techies over four years to work at the centre in the southwestern state for the local enterprises," said the city-based IT behemoth in a statement, here on Saturday.
Arizona Governor Doug Ducey inaugurated the centre in the presence of state officials, company executives, employees and representatives of a few enterprises.
The centre, housed at the Arizona State University (ASU), will focus on autonomous technologies, Internet of Things (IOT), full-stack engineering, data science and cyber security.
"Our investment in the centre will attract local and global talent. Hiring is underway to recruit around 500 techies by 2020 and reduce the IT skills gap in the state," it said.
Infosys Chief Executive Salil Parikh said the Arizona centre, the company's sixth of its kind in the US since 2017, was set up to help local enterprises go for digital transformation at the earliest.
"The centre allows us to collaborate with our clients across the country in an agile manner," said Parekh.
The centre will also leverage and empower the workforce to bridge the skill gap in the market and accelerate the digital agenda of its clients.
"Our focus will be on harnessing, modelling and scaling a new model for workforce development in the US, where the private sector has a key role to implement it (model) or learning and on-the-job training," said company's president Ravi Kumar.
The centre boasts of living labs, showcasing prototypes in virtual reality, augmented reality and robotic technologies and will help foster co-creation, training and collaboration.
Lauding Infosys for foraying into the state, Ducey said its presence reinforced Arizona's reputation as a tech hub and one of the best places to relocate and expand.
The centre will allow the company to develop cross-functional solutions to pressing business challenges in machine learning, artificial intelligence, user experience and advanced digital technologies, such as big data and cloud.
As part of its commitment to workforce development and bridging the STEM (Science, Technology, Engineering and Mathematics) skill gap in the US, the $11 billion outsourcing firm also announced a partnership with InStride to allow its employees complete degree programmes and education courses through ASU.
"Infosys' commitment to Arizona and learning speaks of the strength of talent in our community. We welcome it as a partner that will boost our competitiveness in the global economy," said ASU president Michael Crow.