In "2.0", Rajinikanth will reprise the role of Dr Vaseegaran/ Chitti.
Akshay, who is the new addition to the franchise, will play the antagonist, Dr Richard. The actor duo will share screen space for the first time.
The film, directed by Shankar, is the sequel to his "Enthiran" (2010) that also starred Aishwarya Rai Bachchan.
Shankar took to social media to share the news.
"Hi everyone. At last the vfx companies promised the final delivery date of the vfx shots. The movie will release on November 29, 2018. '2.0' (sic)" he tweeted.
"Get ready for the ultimate clash, '2.0' on November 29, 2018!" Akshay wrote on Twitter.
The movie's release has seen a string of postponements since Diwali 2017, with April being its last scheduled arrival.
"2.0" also features Adil Hussain and Amy Jackson.